Proliferating Cell Nuclear Antigen



Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, i.e. the crystal structure of Proliferating Cell Nuclear Antigen from Archaeglobus fulgidus (1rwz).

3D Structures of Proliferating Cell Nuclear Antigen
Update June 2011

Unliganded PCNA
1rwz – AfPCNA - Archaeglobus fulgidus

3lx1 - TkPCNA1 - Thermococcus kodakarensis

3lx2 - TkPCNA2

3lox, 1plq, 1plr – yPCNA - yeast

3f1x, 3gpm, 3gpn, 3f1w - yPCNA (mutant)

3l0x - yPCNA N fragment + C fragment

3gpe - yPCNA N fragment + SUMO-C fragment

1vym, 1w60 – hPCNA - human

2io4 – SsPCNA B (mutant) + PCNA C - Sulfolobus solfataricus

2hii, 2hik, 2ixi - SsPCNA A + PCNA B + PCNA C

2nti - SsPCNA A + PCNA B (mutant) + PCNA C

2ijx - SsPCNA A

1iz4, 1iz5 – PfPCNA (mutant) - Pyrococcus furiosus

3hi8, 3ifv - PCNA - Haloferax volcanii

3aix, 3aiz - PCNA B + PCNA C – Sulfolobus tokodaii

3p91 – PCNA – Entamoeba histoytiica

PCNA + Dpo
2zvk – hPCNA + hDpo ε

2zvl – hPCNA + hDpo κ

2zvm – hPCNA + hDpo τ

3fds – SsPCNA B + PCNA C + SsDpo IV

3a2f - PfPCNA + Dpo

PCNA complexes
1vyj, 1u76, 1u7b – hPCNA + peptide

1axc - hPCNA + P21/WAF1 C-terminat

1ul1 - hPCNA + Flap exonuclease-1

3p87 - hPCNA + RNase H2 subunit B (mutant)

3p83 - AfPCNA + RNase H2

1rxm – AfPCNA + Flap exonuclease-1 peptide

1rxz - AfPCNA + Flap structure-specific endonuclease

3l0w, 3l10 - yPCNA + monoubiquinated PCNA

1sxj – yPCNA + replication factor C

2od8 - yPCNA + DNA ligase fragment

3k4x - yPCNA + DNA

2izo - SsPCNA B + PCNA C + Flap structure-specific endonuclease

1isq - PfPCNA (mutant) + replication factor C large subunit

2zvw - PCNA + cyclin-dependent kinase inhibitor 1 - Arabidopsis thaliana